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•  A two-arm, single-blinded, randomized controlled trial design on  adult everyday smokers (at least 1    cigarette per day on average and  have smoked at least 100 cigarettes).

Mumbai, Pune, Kolkata and Mangalore

One Year.

• Minimum sample size: 500
• Assuming about 40% drop out of 200 participants we will enroll 700 participants across all centres.
• Computer generated randomization.
• An open list of random numbers will be assigned to the participants.

• Minimum 250 participants each in Intervention Group (IG) and Control Group (CG).
• Total minimum 500 participants will be included in the study. Assuming there will be about 40%
• drop out, we will enroll about 700 participants in order to achieve the test and control
• size of 350 in each arm, minimum target being 250 in total excluding the dropouts.

• Eligible participants will be  randomly assigned to either do the QuitSure    program [the IG] or will simply be given brief advice to quit  smoking [the    CG]. 
• Both point prevalence (PPA) abstinence and  prolonged abstinence (PA)    outcomes will be recorded via  self-reporting via phone, online, or in-person at the 7-day, 30-day,  3-month, and 6-month time points post the quit date (in the case of  the IG) or post the quit date defined in by the CG.
• At the 30-day and  6- month time points we will also biochemically verify self-reported  data    by testing saliva cotinine (non-invasive test) in the  participants.

Participant Blinded. The instruction given to the participant 

• Smokes at least 1 cigarette per day on average and has smoked at least 100 cigarettes till date.
• Agrees to participate in a smoking cessation treatment program with written informed consent.
• Must be an adult over 18 years of age.
• Are, at minimum, proficient in the written and spoken English Language.
• Must be an everyday smoker: Should currently smoke 01 (one) or more cigarettes per day on an average (indicating sufficient dependence on nicotine)
  and have smoked at least 100 cigarettes (indicating sufficient exposure of the
  body to nicotine) on a regular basis.
• Have daily access to an Android or iOS smartphone.
• Salivary cotinine test positive on the first visit.
• Can use a smartphone without difficulty.
• Rinsed mouth thoroughly with water 10 minutes before sample is collected.
• Inclusion criteria for controls: Age and gender matched controls.

• Has already quit smoking and is currently not smoking.
  If a doctor has advised the participant not to quit cold-turkey.
• History of severe mental illness/ psychiatric illness or under current treatment for psychiatric illness such as schizophrenia or other primary psychotic disorders, BPAD, catatonia, OCD, dissociative disorders, eating disorders,
  personality disorders.
• Unable to attend follow-up clinic visits during the study period.
• Started taking a smoking cessation medication within 1 year before the
  registration.
• Planned to use any smoking cessation aids and/or to participate in any kind of smoking-cessation activities (not limited to smoking cessation therapy) outside
  of the trial.
• Consumed a major meal within 60 minutes before the test.
• Consumed alcohol within 12 hours before the test.
• Consumed foods like broccoli, cabbage, mustard, garlic, radishes, almonds and
  horseradish within 12 hours.
• Persons working with metal, the related occupations include electroplaters and
  people who refine precious metals.
• Tobacco workers.